Call for Proposals: University of Bordeaux & China Scholarship Coucil PhD Scholarships

 
The application should be completed and sent back to the French Project Research Supervisor by February 24th 2017.

IDENTIFICATION OF THE THESIS SUBJECT

The Selection Committee will focus on proposals from teams that already have collaborations with China. This call aims at perpetuating existing collaborations.

Project supervisor (name, surname, phone, email):

LE BON-JEGO Morgane

morgane.jego@u-bordeaux.fr

+33 (0)5 57 57 57 64 or +33 (0)6 78 13 46 59

Laboratory:

Institut des Maladies Neurodégénératives, CNRS UMR 5293
Université de Bordeaux
146, rue Léo Saignat
Zone Nord Bâtiment 1A 3ème étage
33 076 Bordeaux Cedex

Doctoral School:

Ecole Doctorale des Sciences de la Vie et de la Santé, Université de Bordeaux

PhD Research Offer (title and short presentation)

“Cellular and synaptic basis of primary motor cortical activity in Parkinson’s disease.”

The host laboratory is working on dysfunction of neural networks in neurodegenerative disorders. Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, a structure of the basal ganglia involved in the control of voluntary movement. The resulting lack of dopamine is the cause of the typical symptoms observed: rigidity, resting tremor and akynesia.

Most of the current research focuses on the basal ganglia, little work is done on motor cortex. However, it has been shown in vivo that the activity of neurons in the primary motor cortex is altered in monkeys rendered parkinsonian. Indeed, neurons exhibiting tonic activity in normal condition switch to bursts of discharge which are synchronized among neurons in the primate model of Parkinson’s disease.

The aim of the thesis is to decipher the function of these motor cortical microcircuits on acute slice of mice primary motor cortex under physiological and pathophysiological conditions. Using an experimental approach that combines conventional electrophysiology techniques (patch clamp), functional calcium imaging to monitor in real time the activity of many neurons and optogenetic, we will 1) investigate in vitro the role of the dopaminergic innervation in the complex activity of cortical microcircuits in physiological and pathophysiological conditions, 2) try to understand and determine the cellular and synaptic mechanisms underlying these different patterns of activity.

Candidate’s eligibility

  • Candidates must be citizens and permanent residents of the People’s Republic of China at the time of application
  • Candidates must not be currently working abroad
  • Successful candidates must return to China upon completion of the studies and/or research
  • Candidates must have a good level of English (or French) language proficiency
  • Candidates should specify in their application that they are applying for the UB/CSC joint scholarship scheme
  • Candidates can only apply for one subject
  • Candidates from Hong-Kong are not eligible

Process

  • Candidates send the completed application form with all the requested documents by February 24th 2017 to the PhD project supervisor at UB.  
  • UB will evaluate the student files, academic performance and English language proficiency of the candidates. Interviews will be conducted by the PhD supervisors via telephone or via videoconference.
  • By March 16th 2017 UB will provide CSC and each qualified candidate with a copy of the admission letter.
  • By the beginning of April 2017, after receiving the admission letter from the University of Bordeaux, candidates must apply to the CSC by completing an application for funding. Forms are available online at http://apply.csc.edu.cn through CSC’s application agencies.
  • CSC will evaluate the candidates according to CSC requirements and priorities. The CSC Council will subsequently provide UB with a final list of scholarship recipients and inform the successful candidates before the end of May 2017.