法国波尔多大学/国家留学基金委合作博士奖学金项目开放申请

 
法国波尔多大学生命科学与健康学院博士生项目开放申请,并将于2017年2月24日截止。

博士项目研究课题(标题及简介)

 “Cellular and synaptic basis of primary motor cortical activity in Parkinson’s disease.”

The host laboratory is working on dysfunction of neural networks in neurodegenerative disorders. Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, a structure of the basal ganglia involved in the control of voluntary movement. The resulting lack of dopamine is the cause of the typical symptoms observed: rigidity, resting tremor and akynesia.

Most of the current research focuses on the basal ganglia, little work is done on motor cortex. However, it has been shown in vivo that the activity of neurons in the primary motor cortex is altered in monkeys rendered parkinsonian. Indeed, neurons exhibiting tonic activity in normal condition switch to bursts of discharge which are synchronized among neurons in the primate model of Parkinson’s disease.

The aim of the thesis is to decipher the function of these motor cortical microcircuits on acute slice of mice primary motor cortex under physiological and pathophysiological conditions. Using an experimental approach that combines conventional electrophysiology techniques (patch clamp), functional calcium imaging to monitor in real time the activity of many neurons and optogenetic, we will 1) investigate in vitro the role of the dopaminergic innervation in the complex activity of cortical microcircuits in physiological and pathophysiological conditions, 2) try to understand and determine the cellular and synaptic mechanisms underlying these different patterns of activity.

项目导师

LE BON-JEGO Morgane

morgane.jego@u-bordeaux.fr

+33 (0)5 57 57 57 64 或 +33 (0)6 78 13 46 59

实验室

Institut des Maladies Neurodégénératives, CNRS UMR 5293

Université de Bordeaux

146, rue Léo Saignat

Zone Nord Bâtiment 1A 3ème étage

33 076 Bordeaux Cedex

学院

波尔多大学生命科学与健康博士学院

申请人需具备以下条件 :

  • 必须为中国公民,并在中国大陆永久居住
  • 目前不在国外工作
  • 完成学业或研究项目后必须返回中国
  • 必须具备良好的英语(或法语)水平
  • 必须在申请时写明申请国家留学基金委/法国波尔多大学合作奖学金项目
  • 只能申请一个课题
  • 不接受香港地区申请者

申请流程:

  • 所有申请材料须在2017年2月24日前向项目导师提交。
  • 学校将对申请人的背景、学习成绩和英语语言能力进行评估。面试将由博士导师通过电话或通过视频会议进行。
  • 学校将于2017年3月16日前发放录取通知书。
  • 学生在拿到录取通知书后,可在2017年4月之后向国家留学基金委申请奖学金。申请表格请到http://apply.csc.edu.cn 下载。
  • 国家留学基金委评估结束后会将奖学金获得者名单于2017年5月底前发送至波尔多大学并告知相关学生。