CALL FOR PROPOSALS UNIVERSITY OF BORDEAUX, FRANCE CHINA SCHOLARSHIP COUNCIL - PhD SCHOLARSCHIPS 2017
Before applying please read all details concerning this call for proposals carefully:
· Candidates must be citizens and permanent residents of the People’s Republic of China at the time of application
· Candidates must not be currently working abroad
· Successful candidates must return to China upon completion of the studies and/or research
· Candidates must have a good level of English (or French) language proficiency
· Candidates should specify in their application that they are applying for the UB/CSC joint scholarship scheme
· Candidates can only apply for one subject
· Candidates from Hong-Kong are not eligible
Please check the procedure and download the Application form.
PhD Research Offer (title and short presentation)
“Cellular and synaptic basis of primary motor cortical activity in Parkinson’s disease.”
The host laboratory is working on dysfunction of neural networks in neurodegenerative disorders. Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, a structure of the basal ganglia involved in the control of voluntary movement. The resulting lack of dopamine is the cause of the typical symptoms observed: rigidity, resting tremor and akynesia.
Most of the current research focuses on the basal ganglia, little work is done on motor cortex. However, it has been shown in vivo that the activity of neurons in the primary motor cortex is altered in monkeys rendered parkinsonian. Indeed, neurons exhibiting tonic activity in normal condition switch to bursts of discharge which are synchronized among neurons in the primate model of Parkinson’s disease.
The aim of the thesis is to decipher the function of these motor cortical microcircuits on acute slice of mice primary motor cortex under physiological and pathophysiological conditions. Using an experimental approach that combines conventional electrophysiology techniques (patch clamp), functional calcium imaging to monitor in real time the activity of many neurons and optogenetic, we will 1) investigate in vitro the role of the dopaminergic innervation in the complex activity of cortical microcircuits in physiological and pathophysiological conditions, 2) try to understand and determine the cellular and synaptic mechanisms underlying these different patterns of activity.